Mycophenolate Mofetil (MMF) for the treatment of juvenile onset systemic lupus erythematosus
نویسندگان
چکیده
Address: 1Department of Biomedicine, Division of Rheumatology, Transition Unit, University of Florence, Florence, Italy, 2Department of Paediatrics, Rheumatology Unit, University of Padua, Padua, Italy, 3Department of Paediatrics, Rheumatology Unit, University of Messina, Messina, Italy and 4A. Meyer Children's Hospital, Rheumatology Unit, University of Florence, Florence, Italy * Corresponding author
منابع مشابه
Mycophenolate mofetil in the treatment of systemic lupus erythematosus.
PURPOSE OF REVIEW Clinicians are increasingly using mycophenolate mofetil (MMF) for the treatment of systemic lupus erythematosus (SLE). This review will discuss the key studies that have contributed to our understanding of the efficacy and safety of MMF in the treatment of SLE. RECENT FINDINGS The Aspreva Lupus Management Study (ALMS) firmly established that MMF is equivalent to intravenous ...
متن کاملMycophenolate mofetil for systemic lupus erythematosus refractory to other immunosuppressive agents.
BACKGROUND Mycophenolate mofetil (MMF) is an immunosuppressive drug widely used in solid organ transplantation, and it may play an increasing role in autoimmune disease. MMF has been introduced as a novel immunosuppressive agent in systemic lupus erythematosus (SLE), often in patients intolerant of or resistant to conventional immunosuppressive regimens. METHODS We studied 21 patients with SL...
متن کاملSkin manifestations of systemic lupus erythematosus refractory to multiple treatment modalities: poor results with mycophenolate mofetil.
OBJECTIVE Skin disease can be one of the most refractory clinical manifestations of systemic lupus erythematosus (SLE). The standard therapy consists of sunscreens, topical corticosteroids and antimalarials. However in difficult cases a variety of other drugs have been tried. Here we describe our clinical experience with mycophenolate mofetil (MMF) in patients with cutaneous manifestations of S...
متن کاملSuccessful Treatment with Mycophenolate Mofetil and Tacrolimus in Juvenile Severe Lupus Nephritis
Lupus nephritis (LN) of juvenile onset often has severe disease presentation. Despite aggressive induction therapy, up to 20% of patients with LN are resistant to initial therapy and up to 44% suffer a renal relapse. However, there is no consensus on an appropriate therapeutic regimen for refractory LN. We report a 13-year-old girl with recurrent LN who was not taking her medications. At age of...
متن کاملSuccessful Treatment of Refractory Thrombocytopenia with Mycophenolate Mofetil in a Patient with Systemic Lupus Erythematosus
While mild thrombocytopenia in systemic lupus erythematosus (SLE) is frequently seen in the context of active disease, severe thrombocytopenia causing significant bleeding is not that common. Corticosteroids are considered the first line therapy for severe thrombocytopenia in SLE. Second-line therapeutic agents or splenectomy have been reported to be effective for patients who fail to respond t...
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2008